TRPS1 MODULATES CHROMATIN ACCESSIBILITY TO REGULATE ESTROGEN RECEPTOR ALPHA (ER) BINDING AND ER TARGET GENE EXPRESSION IN LUMINAL BREAST CANCER CELLS.

Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout.We introduced an inducible degron tag into the gibson sg fireburst native TRPS1 locus within a luminal breast cancer cell line to identi

Abstract Background Bird genomes have very different compositional structure compared with other warm-blooded animals.The variation in the base skew rules in the vertebrate genomes remains puzzling, but it must relate somehow to large-scale genome evolution.Current research is inclined to relate base skew with mutations and their fixation.Here we w

Abstract Background We examined whether impaired renal function causes thickening of the aortic valve leaflets in hyperlipidemic apoE-knockout (apoE-/-) mice, and whether the putative effect on the aortic valves could be prevented by inhibiting the angiotensin-converting enzyme (ACE) with enalapril.Methods Thickening of the aortic valve leaflets in

BackgroundPulmonary alveolar proteinosis (PAP) flybar bumper car wheel replacement is a rare syndrome first described by Rosen et al.in 1958.Despite our considerably evolved understanding of PAP over the past decades, no bibliometric studies have been reported on this field.We aimed to analyze and visualize the research hotspots and current trends

Since double-suction centrifugal pumps consume quantities of trinity bay vodka energy, revealing critical factors for energy dissipation is helpful for energy-saving design.This study aims to investigate the relationship between energy dissipation and vortex based on Rortex method in a double-suction centrifugal pump.Detached eddy simulation was ap